ABSTRACT
Objective@#To investigate the effects of compound Haishe capsule combined with rivastigmine capsule on serum thyroid hormone, inflammatory factors and coagulation function in patients with Alzheimer's disease(AD).@*Methods@#From January 2016 to January 2018, 74 patients with AD in the Seventh People's Hospital of Hangzhou were randomly divided into control group and observation group according to the digital table, with 37 cases in each group.The control group was treated with rivastigmine capsule, while the observation group was treated with compound Haishe capsule on the basis of the control group.The two groups were treated for 6 months.The therapeutic effects of the two groups were compared.The changes of BEHAVE-AD and ADAS-Cog scores, thyroid hormones, inflammatory factors and coagulation function were compared before and after treatment.@*Results@#The total effective rate of the observation group was 94.59%(35/37), which was higher than 72.97%(27/37) of the control group(u=6.366, P<0.05). After treatment, the scores of BEHAVE-AD and ADAS-Cog in the observation group were (4.87±0.64)points, (14.28±1.82)points, respectively, which were lower than those in the control group[(8.91±1.07)points, (18.93±1.25)points](t=19.710, 12.811, all P<0.05). After treatment, the level of FT4 in the observation group was (13.09±0.71)pmol/L, which was higher than (12.30±0.52)pmol/L in the control group (t=5.460, P<0.05). After treatment, the levels of CRP and IL-6 in the observation group were (2.13±0.38)mg/L, (31.32±5.64)ng/L, respectively, which were lower than those in the control group[(3.47±0.61)mg/L, (58.93±12.15)ng/L](t=11.342, 12.538, all P<0.05). After treatment, the levels of D-dimer and Fib in the observation group were (519.82±10.29)μg/L, (3.21±0.32)ng/L, respectively, which were lower than those in the control group[(552.31±8.31)μg/L, (4.12±0.49)ng/L](t=14.942, 9.458, all P<0.05).@*Conclusion@#Compound Haishe capsule combined with rivastigmine capsule is effective in the treatment of AD, and can improve thyroid hormone and coagulation function, and reduce the level of inflammatory factors.
ABSTRACT
Objective To investigate the effects of compound Haishe capsule combined with rivastigmine capsule on serum thyroid hormone ,inflammatory factors and coagulation function in patients with Alzheimer＇s disease (AD).Methods From January 2016 to January 2018,74 patients with AD in the Seventh People＇s Hospital of Hangzhou were randomly divided into control group and observation group according to the digital table ,with 37 cases in each group.The control group was treated with rivastigmine capsule ,while the observation group was treated with compound Haishe capsule on the basis of the control group.The two groups were treated for 6 months.The therapeutic effects of the two groups were compared.The changes of BEHAVE-AD and ADAS-Cog scores,thyroid hormones,inflammatory factors and coagulation function were compared before and after treatment.Results The total effective rate of the observation group was 94.59%(35／37),which was higher than 72.97%(27／37) of the control group(u＝6.366,P＜0.05).After treatment, the scores of BEHAVE -AD and ADAS -Cog in the observation group were (4.87 ± 0.64)points,(14.28 ±1.82 ) points, respectively, which were lower than those in the control group [( 8.91 ± 1.07)points,(18.93 ±1.25)points] ( t＝19.710,12.811,all P＜0.05).After treatment,the level of FT4 in the observation group was (13.09 ±0.71) pmol／L,which was higher than (12.30 ±0.52) pmol／L in the control group (t＝5.460,P＜0.05).After treatment,the levels of CRP and IL-6 in the observation group were (2.13 ±0.38)mg／L, (31.32 ±5.64)ng／L,respectively,which were lower than those in the control group [(3.47 ±0.61) mg／L,(58.93 ± 12.15)ng／L](t＝11.342,12.538,all P＜0.05).After treatment,the levels of D-dimer and Fib in the observation group were (519.82 ±10.29) μg／L,(3.21 ±0.32) ng／L,respectively,which were lower than those in the control group[(552.31 ±8.31) μg／L,(4.12 ±0.49) ng／L] ( t＝14.942,9.458,all P＜0.05).Conclusion Compound Haishe capsule combined with rivastigmine capsule is effective in the treatment of AD , and can improve thyroid hormone and coagulation function ,and reduce the level of inflammatory factors.
ABSTRACT
Hydrophidae, one of the precious traditional Chinese medicines, is generally drily preserved to prevent corruption, but it is hard to identify the species of Hydrophidae through the appearance because of the change due to the drying process. The identification through analysis on gene barcode, a new technique in species identification, can avoid this problem. The gene barcodes of the 5 species of Hydrophidae, Lapemis hardwickii, Hydrophis fasciatus, Aipysurus eydouxii, Hydrophis belcher and Hydrophis lamberti, were acquired through DNA extraction and gene sequencing. These barcodes were then in sequence alignment and test the identification efficiency by BLAST. Our results showed that the 16S rDNA sequences identified Hydrophidae briefly and the COI sequenceshad obvious difference between intra-and inter-species, indicating that DNA bar-coding was an efficiency method of Hydrophidae identification.